Original Syndol from South Africa available online in the UK.

Syndol Information

Page 2

What is Syndol used for?

  • Short-term (up to three days) treatment of acute, moderate pain which is not relieved by paracetamol, ibuprofen or aspirin alone.


  • This medicine may cause drowsiness. If affected do not drive or operate machinery. Alcohol should be avoided.
  • Do not take this medicine with any other products that contain paracetamol or codeine. Many over-the-counter painkillers and cold and flu remedies contain paracetamol and codeine. It is important to check the ingredients of any medicines you buy without a prescription before taking them in combination with this medicine. Seek further advice from your pharmacist.
  • An overdose of paracetamol is dangerous and capable of causing serious damage to the liver and kidneys. You should never exceed the dose stated in the information leaflet supplied with this medicine. Immediate medical advice should be sought in the event of an overdose with this medicine, even if you feel well, because of the risk of delayed, serious liver damage.
  • Alcohol increases the risk of liver damage that can occur if an overdose of paracetamol is taken. The hazards of paracetamol overdose are greater in persistent heavy drinkers and in people with alcoholic liver disease.
  • Do not take this medicine for longer than three days without consulting your doctor. If codeine is taken regularly for long periods of time, the body can become tolerant to it and it may become less effective at relieving pain. With prolonged use, the body may also become dependent on codeine. As a result, when you then stop taking the medicine you may get withdrawal symptoms such as restlessness and irritability.
  • If you find you need to use this medicine all the time you should consult your doctor for advice.
  • Taking a painkiller for headaches too often or for too long can actually make the headaches worse.

Use Syndol with caution in

  • Elderly people.
  • Weak or debilitated people.
  • Kidney disease.
  • Liver disease.
  • High blood pressure (hypertension).
  • Underactive thyroid gland (hypothyroidism).
  • Decreased production of natural steroid hormones from the adrenal glands (adrenocortical insufficiency).
  • Enlarged prostate gland (prostatic hypertrophy).
  • Reduced blood flow to vital internal organs (shock).
  • Disease causing obstruction of the bowel.
  • Acute abdominal conditions such as appendicitis.
  • People who have recently had surgery on the stomach or intestines.
  • Gall stones.
  • Abnormal muscle weakness (myasthenia gravis)
  • History of irregular heart beats (arrhythmias).
  • History of convulsions, eg: epilepsy
  • People with a history of drug abuse or emotional instability.

Not to be used in

  • Children under 12 years of age.
  • Allergy to opioid painkillers.

This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

  • Paracetamol and doxylamine are not known to be harmful when used during pregnancy. However, the safety of codeine has not been established. If codeine is used in the third trimester it may cause withdrawal symptoms in the baby after birth. As a result, this medicine should be avoided during pregnancy, and only used if the expected benefit to the mother outweighs any potential risk to the infant. Seek medical advice from your doctor before using this medicine if you are pregnant.
  • Doxylamine may pass into breast milk, but its effects on a nursing infant are unknown. Paracetamol and codeine may pass into breast milk in amounts that are probably too small to be harmful in most people. However, on very rare occasions, codeine taken by a nursing mother may cause side effects in the breastfed baby. These side effects may include drowsiness or sedation, difficulty breastfeeding, vomiting, breathing difficulties and floppiness in the nursing baby. The baby may be more likely to experience side effects if the mother experiences side effects such as drowsiness, nausea, vomiting, loss of appetite or breathing difficulties after taking codeine. You should seek medical advice from your doctor before taking this medicine if you are breastfeeding. You should stop taking this medicine and consult your doctor immediately or seek emergency medical care if your baby shows any of the symptoms just mentioned.

Label warnings

  • Do not take more than two at any one time. Do not take more than eight in 24 hours.
  • Do not take this medication with any other products containing paracetamol.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.

  • Drowsiness.
  • Dizziness.
  • Constipation.
  • Nausea and vomiting.
  • Sweating.
  • Flushing.
  • Blurred vision.
  • Dry mouth.
  • A drop in blood pressure that occurs when going from lying down to sitting or standing, which results in dizziness and lightheadedness (postural hypotension).
  • A general feeling of being unwell (malaise).
  • Headache.
  • Loss of appetite.
  • Difficulty passing urine.
  • Awareness of your heartbeat (palpitations).
  • Slowed heart rate.
  • Slow, shallow breathing (respiratory depression).
  • Skin rashes.

The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

If you are already taking any other medicines, including those bought without a prescription and herbal medicines, it is important to check with your doctor or pharmacist before you take this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while you are taking this one, to make sure that the combination is safe.

You should not take other medicines that contain paracetamol in combination with this medicine, as this can easily result in exceeding the maximum recommended daily dose of paracetamol. Many cold and flu remedies and over-the-counter painkillers contain paracetamol, so be sure to check the ingredients of any other medicines before taking them with this one.

This medicine should be used with caution in people taking a monoamine oxidase inhibitor (MAOI), for example the antidepressants phenelzine, tranylcypromine or Isocarboxacid. Ask your doctor or pharmacist for advice before taking this medicine if you have taken an MAOI in the last 14 days.

Here may be an increased risk of drowsiness if this medicine is taken with any of the following (which can also cause drowsiness):

  • Antipsychotics, eg: Haloperidol
  • Barbiturates, eg: Phenobarbital, Amobarbital.
  • Benzodiazepines, eg: Diazepam,  Temazepam.
  • Other opioids, eg: Morphine, Dihydrocodeine.
  • Sedating antihistamines, eg: Chlorphenamine, hydroxyzine.
  • Sleeping tablets, eg: Zopiclone.
  • Tricyclic antidepressants, eg Amitriptyline.

Cholestyramine reduces the absorption of Paracetamol from the gut. It should not be taken within an hour of taking Paracetamol or the effect of the Paracetamol will be reduced.

Metoclopramide and Domperidone may increase the absorption of Paracetamol from the gut. However, Codeine may oppose the effects of Metoclopramide and Domperidone on the gut.

Long-term or regular use of paracetamol may increase the anti-blood-clotting effect of Warfarin and other anticoagulant medicines, leading to an increased risk of bleeding. This effect does not occur with occasional painkilling doses. If you are taking an anticoagulant medicine and you are also taking this medicine regularly, your blood clotting time (INR) should be regularly monitored.

There may be an increased risk of constipation if this medicine is taken in combination with any of the following medicines:

  • Anticholinergic medicines for Parkinson's disease.
  • Anticholinergic medicines for urinary incontinence.
  • Loperamide.
  • Strong opioid painkillers such as Morphine or Dihydrocodeine./li>

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